fbpx

$1.1 million awarded to cardiology researcher Anand Ganesan and team

Reading Time: 3 minutes

 

How ventricular fibrillation will behave in an individual patient can be accurately modelled and predicted using a single mathematical equation, according to researchers at Flinders University.

Ventricular fibrillation (VF) is a life-threatening heart rhythm, or arrhythmia, that causes the heart to beat irregularly and is one of the leading causes of sudden death in Australia.

The findings, recently published in the journal Heart Rhythmcould be used to improve patient treatment, including identifying when to intervene or to develop individualised treatment plans that can work more effectively.

Developed by Dr Dhani Dharmaprani from the Flinders Heart Rhythm Research Group in the College of Medicine and Public Health, led by Associate Professor Anand Ganesan, the research team studied the statistical properties of VF, identifying the unique patterns that consistently occurred in human patients, as well as animal and computer models of VF in the heart.

 The team, led by Associate Professor Ganesan, was last week awarded a $1.1 million dollar grant from the National Health and Medical Research Foundation to continue their research. The paper was recently accepted into one of the disciplines most competitive early-career competitions: The Heart Rhythm Society Young Investigator Award, alongside finalists from John Hopkins, The Mayo Clinic and Harvard Medical School.

The work was supported by the National Health and Medical Research Council of Australia Project Grant and National Heart Foundation of Australia.

READ ALSO: Indian-origin breast cancer researcher awarded $8 million grant

Dr Dhani Dharmaprani. Source: Twitter
Dr Dhani Dharmaprani. Source: Twitter

“The issue we have with VF is that because the rhythm is so chaotic it’s been very difficult to fully understand the mechanisms that are responsible for the disorder,” says Dr Dharmaprani, a Biomedical Engineer and Postdoctoral Research Associate in Cardiac Electrophysiology.

“This is further complicated by the fact that everyone’s heart is unique, so how the heart reacts during VF changes from patient to patient.

“However, by identifying the characteristics that consistently occurred, we were able to demonstrate for the first time that a single mathematical equation could be used to accurately model and then predict the behaviour of VF.”

The equation uses principles from a branch of mathematics known as renewal theory to predict the population dynamics of ‘rotors’ – mini tornadoes of electricity found in the heart during VF. These rotors are responsible for giving rise to VF’s chaotic heart rhythm, and therefore understanding their dynamics is central to treating the disorder.

The researchers say when applied, the equation could be used to improve patient care in two distinct ways.

“Firstly, the equation seems to predict whether fibrillation will continue to persist, or whether it will stop on its own, this could be important as it could help us identify between patients that require treatment and those where no intervention is needed,” says senior author Associate Professor Anand Ganesan, a practising cardiologist and Matthew Flinders Fellow in Electrophysiology at Flinders University.

“Secondly, because the mathematical equation can model how an individual patient will react to VF, we can use it to potentially develop individualised treatments that work much more effectively.”

Previous research has also demonstrated the equation can be applied to atrial fibrillation (AF), another form of heart arrhythmia that is the most common in the world.

The next step for the research team is to translate these findings towards potential therapies, including using the equation to develop patient-specific computer models that accurately replicate patient dynamics, and understanding how this equation relates to clinical characteristics.

 

- Advertisement -

Related Articles

LEAVE A REPLY

Please enter your comment!
Please enter your name here

- Advertisement -
- Advertisement -

Podcasts

Let’s Talk Boosters: Indian Link podcast

0
  In LET'S TALK BOOSTERS, a new podcast series by Indian Link, host Ekta Sharma quizzes Dr Kritman Dhamoon of Blacktown Hospital Sydney about booster...
Frontline worker Parita Patel (inset). Image supplied

‘Serving the community’: COVID testing in remote NSW

0
  The past two years have been a rollercoaster of COVID-19 related turmoil; from isolating lockdowns, closed borders, to trying to help Indians in the...

Ep 9: What do young Indians want from love?

0
  Growing up in Indian culture, most of us know that love has never been as popular as marriage. Even in the movies, the main...
- Advertisement -

Latest News

Review: Dhaakad

0
  Director Razneesh Ghai's Dhaakad is an action-packed, stylishly mounted but twisted thriller that has the feel of a graphic novel. Designed as an espionage thriller,...
scott morrison playing cricket

Seeing the 2022 Federal Elections through the eyes of a cricket...

0
  On ABC Sydney radio this week (Journos’ Forum with Richard Glover on the Drive show), Indian Link’s Pawan Luthra looked at the 2022 Federal...
gaganyaan discovery +

Review: Gaganyaan – Bharat Ki Antariksh Udaan (Discovery+)

0
  Gaganyaan, a 47-minute documentary streaming on discovery+, showcases India's ambitious odyssey of sending Indian astronauts into space in an Indian spacecraft by 2023. The film...
heavy metal

Ask Auntyji: Heavy metal vs. my boys arguing

0
  Dear Auntyji I am an Australian, married to a lady of Indian descent. I occasionally read your columns and need an online dictionary to understand...

Feel in awe at Vivid Sydney

0
  There are plenty of awesome activities in Sydney all year around. Nearly every month sees a fiesta, embracing themes ranging from art, culture, theatre,...